The anti-thrombotic activity of surfactins

The anti-thrombotic activity of surfactins

Platelet aggregation was inhibited and the density of platelet-rich plasma (PRP) clots was decreased by the preincubation of PRP with surfactins, an acidic lipopeptide of Bacillus subtilis complex BC1212 isolated from soybean paste, in dose-dependent manner. Our findings suggest that surfactins are...

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Veröffentlicht in:Journal of veterinary science (Suwŏn-si, Korea) 2005, 6(4), , pp.353-355
Hauptverfasser: Lim, J.H. (Chungnam National University, Daejeon, Republic of Korea), Hwang, M.H. (Kyungpook National University, Daegu, Republic of Korea), Park, B.K. (Chungnam National University, Daejeon, Republic of Korea), Kim, M.S. (Chungnam National University, Daejeon, Republic of Korea), Yun, H.I. (Chungnam National University, Daejeon, Republic of Korea), E-mail: hiyun@cnu.ac.kr, Rhee, M.H. (Kyungpook National University, Daegu, Republic of Korea), Park, S.C. (Kyungpook National University, Daegu, Republic of Korea)
Format: Artikel
Sprache:eng
Schlagworte:
anti-platelet aggregation
Bacillus subtilis - metabolism
Blood Platelets - drug effects
Fibrinolytic Agents - pharmacology
Humans
Lipopeptides
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Platelet Aggregation Inhibitors - pharmacology
platelet rich plasma
PLATELETS
surfactins
THROMBOCYTE
TROMBOCITOS
수의학
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Beschreibung
Zusammenfassung:Platelet aggregation was inhibited and the density of platelet-rich plasma (PRP) clots was decreased by the preincubation of PRP with surfactins, an acidic lipopeptide of Bacillus subtilis complex BC1212 isolated from soybean paste, in dose-dependent manner. Our findings suggest that surfactins are able to prevent a platelet aggregation leading to an inhibition of additional fibrin clot formation, and to enhance fibrinolysis with facilitated diffusion of fibrinolytic agents.
ISSN:1229-845X
1976-555X
DOI:10.4142/jvs.2005.6.4.353