Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs

This study was to determine the effects of allogenic umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) and recombinant methionyl human granulocyte colony-stimulating factor (rmhGCSF) on a canine spinal cord injury model after balloon compression at the first lumbar vertebra. Twenty-fi...

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Veröffentlicht in:	Journal of veterinary science (Suwŏn-si, Korea) 2007, 8(3), , pp.275-282
Hauptverfasser:	Lim, J.H. (Seoul National University, Seoul, Republic of Korea), Byeon, Y.E. (Seoul National University, Seoul, Republic of Korea), Ryu, H.H. (Seoul National University, Seoul, Republic of Korea), Jeong, Y.H. (Seoul National University, Seoul, Republic of Korea), Lee, Y.W. (Chungnam National University, Daejeon, Republic of Korea), Kim, W.H. (Seoul National University, Seoul, Republic of Korea), Kang, K.S. (Seoul National University, Seoul, Republic of Korea), E-mail: kangpub@snu.ac.kr, Kweon, O.K. (Seoul National University, Seoul, Republic of Korea), E-mail: ohkweon@snu.ac.kr
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - physiology CHIEN Cord Blood Stem Cell Transplantation - methods Cord Blood Stem Cell Transplantation - veterinary Dog Diseases - pathology Dog Diseases - therapy DOGS Evoked Potentials, Somatosensory - physiology Histocytochemistry - veterinary Magnetic Resonance Imaging - veterinary Original PERRO Random Allocation Spinal Cord Injuries - pathology Spinal Cord Injuries - therapy Spinal Cord Injuries - veterinary spinal cord injury stem cell TRANSPLANTATION TRASPLANTES umbilical cord blood Videotape Recording 수의학
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Beschreibung
Zusammenfassung:	This study was to determine the effects of allogenic umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) and recombinant methionyl human granulocyte colony-stimulating factor (rmhGCSF) on a canine spinal cord injury model after balloon compression at the first lumbar vertebra. Twenty-five adult mongrel dogs were assigned to five groups according to treatment after a spinal cord injury: no treatment (CN); saline treatment (CP); rmhGCSF treatment (G); UCB-MSCs treatment (UCB-MSC); co-treatment (UCBG).
ISSN:	1229-845X 1976-555X
DOI:	10.4142/jvs.2007.8.3.275