Effect of Long-term Fenofibrate Therapy on Serum Creatinine and Its Reversibility in Hypertriglyceridemic Patients with Hypertension

Objective: Previous studies have shown that fenofibrate therapy increases serum creatinine level and that there is a returnof serum creatinine to baseline level after the discontinuation of the drug. We evaluated the effect of long-term fenofibratetherapy on creatinine levels and its reversibility in patients with hypertension and hypertriglyceridemia. Methods: This retrospective study enrolled 54 hypertensive and hypertriglyceridemic patients taking fenofibrate for 3-6years (Fenofibrate group) and 30 control patients with similar age, sex, follow-up duration, and creatinine levels (Controlgroup). In 23 patients taking fenofibrate with low triglyceride level and/or with high creatinine levels, fenofibrate was discontinued,and creatinine levels were measured after 2 months. Results: Creatinine levels increased in both the fenofibrate group (from 0.91±0.18 mg/dL to 1.09±0.23 mg/dL, p