Cholinesterase Inhibitory Activities of Alkaloids from Corydalis Tuber

Cholinesterase Inhibitory Activities of Alkaloids from Corydalis Tuber

Several isoquinoline alkaloids (1 - 18), which have basic chemical structures as protoberberine and aporphine skeletones, were evaluated for their inhibitory activities on AChE and BuChE. Among them, compounds 3, 4, 6, 8 and 12 showed the potent AchE activity with the IC∧50 values ranging from 10.2±...

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Veröffentlicht in:Natural product sciences 2011, 17(2), , pp.108-112
Hauptverfasser: Hung, Tran Manh, University of Natural Science, National University Hochiminh city, Hochiminh, Vietnam, Thuong, Phuong Thien, National Institute of Medicinal Materials, Hanoi, Vietnam, Nhan, Nguyen Trung, University of Natural Science, National University Hochiminh city, Hochiminh, Vietnam, Thanh Mai, Nguyen Thi, University of Natural Science, National University Hochiminh city, Hochiminh, Vietnam, Quan, Tran Le, University of Natural Science, National University Hochiminh city, Hochiminh, Vietnam, Choi, J.S., Pukyong National University, Busan, Republic of Korea, Woo, M.H., Catholic University of Daegu, Gyungsan, Republic of Korea, Min, B.S., Catholic University of Daegu, Gyungsan, Republic of Korea, Bae, K.H., Chungnam National University, Daejeon, Republic of Korea
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer's disease
CHOLINESTERASE
COLINESTERASA
Corydalis turtschaninovii
Isoquinoline alkaloids
PAPAVERACEAE
Structures and activity relationship
약학
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Zusammenfassung:Several isoquinoline alkaloids (1 - 18), which have basic chemical structures as protoberberine and aporphine skeletones, were evaluated for their inhibitory activities on AChE and BuChE. Among them, compounds 3, 4, 6, 8 and 12 showed the potent AchE activity with the IC∧50 values ranging from 10.2±0.5 μM to 24.5±1.6 μM, meanwhile, compound 14 - 17 exhibited strong inhibitory activity with IC∧50 values from 2.1±0.2 to 5.5±0.3 μM. Compounds 14 - 17 exhibited selective inhibition for AChE compared with BuChE. The isoquinoline alkaloid possesses aromatic methylenedioxy groups and quaternary nitrogen atoms are crucial for the anti-cholinesterase inhibitory activity.
ISSN:1226-3907
2288-9027