전호의 멜라닌 생성 억제 물질

A chemical investigation of Peucedanum praeruptorum has resulted in the isolation of 3 khellactone derivatives, which have inhibitory effects on melanogenesis in Bl6 mouse melanoma cell lines. The khellactone derivatives were isolated from the crude extract of the roots of Pecedanum praeruptorum by...

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Veröffentlicht in:생약학회지 2002, 33(4), , pp.395-398
Hauptverfasser: 김청택(Cheong Taek Kim), 김원찬(Won Chan Kim), 진무현(Mu Hyun Jin), 김호정(Ho Jeong Kim), 강상진(Sang Jin Kang), 강세훈(She Hoon Kang), 정민환(Min Hwan Jung), 임영희(Young Hee Lim)
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Zusammenfassung:A chemical investigation of Peucedanum praeruptorum has resulted in the isolation of 3 khellactone derivatives, which have inhibitory effects on melanogenesis in Bl6 mouse melanoma cell lines. The khellactone derivatives were isolated from the crude extract of the roots of Pecedanum praeruptorum by a combination of adsorption chromatography and HPLC. The structlues of isolated compounds were identified as 3',4'- diangeloyl-cis-khellactone, 3'-angeloyl- 4'- senecioyl-cis-khel- lactone and,3', 4'-disenecioyl-cis-khellactone by $^1H\;NMR$, $^{13}C\;NMR$ and mass spectral studies and by comparisons of spectral data with reported literatures.
ISSN:0253-3073
2288-9299