LC-QTOF-MS를 활용한 현미 중 동물용의약품의 정량 분석

SPE cartridge clean-up method for simultaneous determination of veterinary pharmaceuticals (VPs) in brown rice was developed and validated by LC-QTOF-MS. The clean-up method was established with HLB (500 mg, 6 mL) cartridges for VPs in brown rice, and the eluate was analyzed to quantify the compound...

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Veröffentlicht in:농약과학회지 2017, 21(3), , pp.269-278
Hauptverfasser: 임성진(Sung-Jin Lim), 오영탁(Young-Tak Oh), 노진호(Jin-Ho Ro), 주형곤(Hyeong-Gon Joo), 이민호(Min-Ho Lee), 윤효인(Hyo-In Yoon), 최근형(Geun-Hyoung Choi), 류송희(Song-Hee Ryu), 김단비(Dan-Bi Kim), 박병준(Byung-Jun Park)
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Zusammenfassung:SPE cartridge clean-up method for simultaneous determination of veterinary pharmaceuticals (VPs) in brown rice was developed and validated by LC-QTOF-MS. The clean-up method was established with HLB (500 mg, 6 mL) cartridges for VPs in brown rice, and the eluate was analyzed to quantify the compounds by LC-QTOF-MS. The developed method was validated, and the recovery, RSD, and LOQ of VPs were 70.3-112.0%, 1.1-5.7%, and $0.076-7.6{\mu}g/kg$, respectively. These results showed that the developed method for simultaneous determination of VPs contribute to monitoring of it in agricultural environment and agriculture product. 본 연구는 LC-QTOF-MS를 활용하여 현미 중 동물용의약품 분석을 위한 SPE cartridge 정제방법 및 다성분 동시분석법을 개발하고자 하였다. 현미 중 동물용의약품 분석을 위한 정제 방법은 HLB cartridge (500 mg, 6 mL)를 사용하였고, 그 용리액을 LC-QTOF-MS로 분석하였다. 개발된 분석방법의 유효성은 회수율, RSD 및 LOQ로 검증하였으며, 그 값은 각각 70.3-112.0%, 1.1-5.7% 및 $0.076-7.6{\mu}g/kg$ 이었다. 본 연구에서 개발된 동물용의약품 동시분석법은 농업환경 및 농산물 중 이들의 모니터링에 활용될 수 있을 것으로 판단된다.
ISSN:1226-6183
2287-2051
DOI:10.7585/kjps.2017.21.3.269