난치성 두드러기환자에서 발견된 위, 결장에서 발생된 동시성 이중암 1예

Chronic urticaria is a common disabling skin condition. Neoplasm has been case-reported as a comorbid disease with urticaria, although there is no reliable evidence suggesting a strong association between these two conditions. We recently experienced a case of chronic urticaria revealing double primary cancers. A 47-year-old woman was referred to our hospital for chronic generalized urticaria which had started 3 months earlier. She was treated with a combination of oral methylprednisolone, hydroxyzine, mequitazine, fexofenadine, ketotifen, ranitidine, and pranlukast. Nevertheless, her skin lesion did not completely subside. She had a family history of early-onset adenocarcinomas of the stomach and the colon. On gastroscopy and colonoscopy, she was diagnosed with signet ring cell type adenocarcinoma and moderately differentiated adenocarcinoma, respectively. Her urticaria disappeared immediately after radical resection of double primary malignancies, and she became free of urticaria without any medications. Considering the time sequence, malignancies were highly suspicious as a cause of her urticaria. KCI Citation Count: 0