Therapeutic effects of mycobacterial secretory proteins against established asthma in BALB/c mice

Therapeutic effects of mycobacterial secretory proteins against established asthma in BALB/c mice

Live/killed mycobacteria and culture supernatants can suppress asthmatic reactions. This study investigated whether mycobacterial secretory proteins have therapeutic effects on asthma. Mycobacterium bovis bacille Calmette-Guérin (BCG; 2×10(5) CFUs) and mycobacterial secretory proteins (Ag85 complex,...

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Veröffentlicht in:Allergy, asthma & immunology research 2012, Asthma & Immunology Research, 4(4), , pp.214-221
Hauptverfasser: Han, Eui-Ryoung, Choi, Inseon S, Choi, Han-Gyu, Kim, Hwa-Jung
Format: Artikel
Sprache:eng
Schlagworte:
Alveoli
Asthma
BCG
Bronchus
Cell culture
Cell number
Colony-forming cells
Cytokines
gamma -Interferon
Goblet cells
Inflammation
Interleukin 5
Leukocytes (eosinophilic)
methacholine
Mycobacterium bovis
Original
Respiratory tract
Splenocytes
Tuberculosis
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Zusammenfassung:Live/killed mycobacteria and culture supernatants can suppress asthmatic reactions. This study investigated whether mycobacterial secretory proteins have therapeutic effects on asthma. Mycobacterium bovis bacille Calmette-Guérin (BCG; 2×10(5) CFUs) and mycobacterial secretory proteins (Ag85 complex, 38-kDa protein or MPB70; 4 or 20 µg) were administered intraperitoneally to female BALB/c mice with established airway hyperresponsiveness. One week after treatment, the mice underwent a methacholine challenge test, and then inflammatory cell numbers in bronchoalveolar lavage fluid (BAL) and around bronchi (
ISSN:2092-7355
2092-7363
DOI:10.4168/aair.2012.4.4.214