The Smad4/PTEN Expression Pattern Predicts Clinical Outcomes in Colorectal Adenocarcinoma

Smad4 and PTEN are prognostic indicators for various tumor types. Smad4 regulates tumor suppression, whereas PTEN inhibits cell proliferation. We analyzed and compared the performance of Smad4 and PTEN for predicting the prognosis of patients with colorectal adenocarcinoma. Combined expression patte...

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Veröffentlicht in:	Journal of pathology and translational medicine 2018, 52(1), , pp.37-44
Hauptverfasser:	Chung, Yumin, Wi, Young Chan, Kim, Yeseul, Bang, Seong Sik, Yang, Jung-Ho, Jang, Kiseok, Min, Kyueng-Whan, Paik, Seung Sam
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer therapies Cell cycle Cell growth Clinical outcomes Colon neoplasms Colorectal cancer Gene expression Humans Lung cancer Medical prognosis Metastasis Mutation Original Patients Phosphatase Prognosis Prostate Proteins PTEN Smad4 Studies Systematic review Tumors 병리학
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Zusammenfassung:	Smad4 and PTEN are prognostic indicators for various tumor types. Smad4 regulates tumor suppression, whereas PTEN inhibits cell proliferation. We analyzed and compared the performance of Smad4 and PTEN for predicting the prognosis of patients with colorectal adenocarcinoma. Combined expression patterns based on Smad4+/- and PTEN+/- status were evaluated by immunostaining using a tissue microarray of colorectal adenocarcinoma. The relationships between the protein expression and clinicopathological variables were analyzed. Smad4-/PTEN- status was most frequently observed in metastatic adenocarcinoma, followed by primary adenocarcinoma and tubular adenoma (p
ISSN:	2383-7837 2383-7845
DOI:	10.4132/jptm.2017.10.20