Perinatal Outcomes according to Screening Timing in Gestational Diabetic Women with Family History of Diabetes

Objective: To compare perinatal outcomes of gestational diabetic women with a family history of type 2 diabetes mellitus (DM), who were diagnosed through early or late screening. Methods: After 2010, women with a family history of DM underwent 2-step screening at the initial visit, mostly before 16 weeks of gestation. The perinatal outcomes were compared with those of historical cohort screened at 24-28 weeks of gestation between 2005 and 2009. The primary outcomes were complications associated with maternal hyperglycemia such as primary cesarean delivery, large for gestational age (LGA), neonatal hypoglycemia, and fetal anomaly. Results: The risk of gestational diabetes mellitus (GDM) was 20.8% (67/322) in women with a history of DM in a first-degree relative. Women who were screened before 16 weeks of gestation were more likely to have a high level of hemoglobin A1C at diagnosis and receive insulin therapy for glycemic control than the Late-screen group. But odds ratios of LGA, primary cesarean delivery and fetal anomalies compared with normal control were highest in the Late-screen group than in the Early screen group and the Low risk GDM group. Conclusion: Some perinatal outcomes may be more favorable in women with GDM and a family history of DM who were screened before 16 weeks of gestation rather than routinely. KCI Citation Count: 0