Neuroprotection of Alpinia katsumadai Seed Extract against Neuronal Damage in the Ischemic Gerbil Hippocampus is Linked to Altered Brain-Derived Neurotrophic Factor

The extract of Alpinia katsumadai, a member of the family Zingiberaceae, shows anti-inflammatory effects and antioxidant activity. We observed the neuroprotective effects of the extract from Alpinia katsumadai seed (EAKS) against ischemic damage in gerbils administered oral EAKS (25, and 50 mg/kg) o...

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Veröffentlicht in:Laboratory animal research 2011, 27(1), , pp.67-71
Hauptverfasser: Li, Hua, Kangwon National University, Chuncheon, Republic of Korea, Park, J.H., Kangwon National University, Chuncheon, Republic of Korea, Yan, B.C., Hallym University, Chuncheon, Republic of Korea, Yoo, K.Y., Gangneung-Wonju National University, Gangneung, Republic of Korea, Lee, C.H., Seoul National University, Seoul, Republic of Korea, Choi, J.H., Kangwon National University, Chuncheon, Republic of Korea, Hwang, I.K., Seoul National University, Seoul, Republic of Korea, Won, M.H., Kangwon National University, Chuncheon, Republic of Korea
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Sprache:eng
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Zusammenfassung:The extract of Alpinia katsumadai, a member of the family Zingiberaceae, shows anti-inflammatory effects and antioxidant activity. We observed the neuroprotective effects of the extract from Alpinia katsumadai seed (EAKS) against ischemic damage in gerbils administered oral EAKS (25, and 50 mg/kg) once a day for 7 days before transient cerebral ischemia. In the 50 mg/kg EAKS-treated ischemia group, about 67% of neurons in the hippocampal CA1 region (CA1) survived after ischemia/reperfusion (I/R) based on cresyl violet staining. We observed that EAKS treatment significantly maintained brain-derived neurotrophic factor (BDNF) immunoreactivity in the ischemic CA1 region after I/R. In addition, protein levels of BDNF in the 50 mg/kg EAKS-treated ischemia group were much higher than those in the vehicle-treated ischemia group after I/R. These findings indicate that repeated supplementation of EAKS protects neurons from ischemic damage, such that BDNF is distinctively maintained in ischemic areas.
ISSN:1738-6055
2233-7660
DOI:10.5625/lar.2011.27.1.67