SNPs in the coding region of bovine MGAT2 gene are associated with body weight and weight gain

Monoacylglycerol acyltransferase 2 (MGAT2), as a candidate gene for quantitative traits, relates to dietary fat uptake, lipids synthesis and storage, which plays a major role in the absorption of dietary fat by catalyzing the resynthesis of triacylglycerol in enterocytes. In this study, based on DNA...

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Veröffentlicht in:	Genes & genomics 2011, 33(3), , pp.267-272
Hauptverfasser:	Qu, Lian, Northwest AnF University, Yangling, Shaanxi, China, Yang, Mingjuan, Northwest AnF University, Yangling, Shaanxi, China, Zhu, Jinlong, Northwest AnF University, Yangling, Shaanxi, China, Liu, Junxia, Shihezi University, Shihezi, Xinjiang, People's Republic of China, Li, Mijie, Northwest AnF University, Yangling, Shaanxi, China, Zhang, Liangzhi, Northwest AnF University, Yangling, Shaanxi, China, Lan, Xianyong, Northwest AnF University, Yangling, Shaanxi, China, Lei, Chuzhao, Northwest AnF University, Yangling, Shaanxi, China, Zhang, Chunlei, Xuzhou Normal University, Xuzhou, Jiangsu, China, Chen, Hong, Northwest AnF University, Yangling, Shaanxi, China
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Biomedical and Life Sciences BOVIN CATTLE GANADO BOVINO Growth traits Human Genetics Life Sciences MGAT2 Gene Microbial Genetics and Genomics PCR-RFLP Plant Genetics and Genomics Research Article SNP association 생물학
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Zusammenfassung:	Monoacylglycerol acyltransferase 2 (MGAT2), as a candidate gene for quantitative traits, relates to dietary fat uptake, lipids synthesis and storage, which plays a major role in the absorption of dietary fat by catalyzing the resynthesis of triacylglycerol in enterocytes. In this study, based on DNA pool sequencing and PCR-RFLP methods, polymorphisms of the MGAT2 gene were detected in 1145 Chinese indigenous cattle. The results revealed two novel mutations located on exon 1 and exon 5 (NM_001099136.1:m.84G greater than T and 756A greater than G). Hence, we described the HaeIII forced PCR-RFLP method in exon1 and a MluI PCR-RFLP method in exon5 to detect them. In addition, the associations of these polymorphisms with growth traits were evaluated in Nanyang cattle. The results showed that only HaeIII locus was associated with body weight and average daily gain aged 6 months, and individuals with genotype TT showed significantly higher body weight and average daily gain than those with genotype GG.
ISSN:	1976-9571 2092-9293
DOI:	10.1007/s13258-011-0020-6