갈만 추출물의 미백 기능 및 안전성에 대한 임상적 유용성 평가

Melanin is major factor that determines skin color as well as one of the defense systems that prevent the UVinduceddamage. White and clean skin is very important part of the satisfaction of appearance and life quality. The purposeof this clinical study was to investigate the anti-melanogenesis activity for whitening product containing aerial part of Puerarialobata extract (APPL) can be utilized based on the increase in demands for cosmetics, particularly natural products. Atotal of 23 subjects who visited Dermapro Skin Research Center were included in this study. Volunteers were irradiated ata test site with UVA+B to induce pigmentation then applied 3% APPL at the test site for 8 weeks. Changes in visual evaluationon pigmentation, average melanin content were observed, and subjective skin lightness and color improvementswere analyzed. In all parameters measured in this clinical study, APPL treated group showed significant improvement comparedwith the control group. After 4 weeks, subjects with 3% APPL treatment started to improve melanin content andvisual evaluation on pigmentation and skin lightness. Skin colors have improved from 8 weeks of treatment with 3% APPL. The safety of product containing 3% APPL was also confirmed. Indexes of subjective irritation(itching, prickling, tickling,burning, stinging, stiffness, tightening etc.) and objective irritation(erythema, edema, scale, papule etc.) proved that therewas no adverse reaction on skin upon treatment of products. Considering all the results obtained, 3% APPL product canbe used as a safe and effective skin-whitening agent. KCI Citation Count: 0