Antioxidant Effect of Homogentisic Acid on Hydrogen Peroxide Induced Oxidative Stress in Human Lung Fibroblast Cells

Homogentisic acid was found to scavenge intracellular reactive oxygen species (ROS), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and thus prevented lipid peroxidation in human fibroblast (WI 38) cells. The radical scavenging activity of homogentisic acid was found to protect WI 38 cells agains...

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Veröffentlicht in:	Biotechnology and bioprocess engineering 2005, 10(6), , pp.556-563
Hauptverfasser:	Kang, K.A. (Cheju National University, Jeju, Republic of Korea), Chae, S.W. (Cheju National University, Jeju, Republic of Korea), Lee, K.H. (Cheju National University, Jeju, Republic of Korea), Zhang, R. (Cheju National University, Jeju, Republic of Korea), Jung, M.S. (Cheju National University, Jeju, Republic of Korea), You, H.J. (Chosun University, Gwangju, Republic of Korea), Kim, J.S. (Korea Institute of Oriental Medicine, Daejeon, Republic of Korea), Hyun, J.W. (Cheju National University, Jeju, Republic of Korea), E-mail: jinwonh@cheju.ac.kr
Format:	Artikel
Sprache:	eng
Schlagworte:	CATALASA CATALASE ESTRES homogentisic acid OXIDACION OXIDATION OXYDATION STRESS 생물공학
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Zusammenfassung:	Homogentisic acid was found to scavenge intracellular reactive oxygen species (ROS), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and thus prevented lipid peroxidation in human fibroblast (WI 38) cells. The radical scavenging activity of homogentisic acid was found to protect WI 38 cells against hydrogen peroxide (H₂O₂) induced oxidative stress, via the activation of extracellular signal regulated kinase (ERK) protein. Homogentisic acid increased the activity of catalase.
ISSN:	1226-8372 1976-3816
DOI:	10.1007/BF02932294