Anti-Candida Activity of YH-1715R, a New Triazole Derivative

Anti-Candida Activity of YH-1715R, a New Triazole Derivative

YH-1715R, (2R,3R)-2-(2,4-difluorophenyl)-3-(3-methoxy-1,2,4-isothiazol-3-yl-thio)-1-(1H-1,2,4-triazol-1-yl)-2-butanol, a new triazole derivative obtained by the structural modification of fluconazole, was found to exhibit potent anti-Candida activity against a wide variety of Candida albicans (C. al...

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Veröffentlicht in:Journal of microbiology and biotechnology 2004, 14(4), , pp.693-697
Hauptverfasser: Park, K.S. (Yonsei University, Seoul, Republic of Korea), Kang, H.I. (Yuhan Corporation, Kunpo, Republic of Korea), E-mail: peterkang@yuhan.co.kr, Paik, Y.K. (Yonsei University, Seoul, Republic of Korea), Lee, J.W. (Yuhan Corporation, Kunpo, Republic of Korea)
Format: Artikel
Sprache:eng
Schlagworte:
14a-demethylase
AZOLE
AZOLES
Biological and medical sciences
BIOSINTESIS
BIOSYNTHESE
BIOSYNTHESIS
Biotechnology
CANDIDA ALBICANS
ERGOSTEROL
Fundamental and applied biological sciences. Psychology
YH-1715R
생물학
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Zusammenfassung:YH-1715R, (2R,3R)-2-(2,4-difluorophenyl)-3-(3-methoxy-1,2,4-isothiazol-3-yl-thio)-1-(1H-1,2,4-triazol-1-yl)-2-butanol, a new triazole derivative obtained by the structural modification of fluconazole, was found to exhibit potent anti-Candida activity against a wide variety of Candida albicans (C. albicans) (MIC: 0.4-12.5 mg/l). To investigate the mode of action of YH-1715R, its effect on ergosterol biosynthesis in cell-free extracts and whole cells of C. albicans was examined.
ISSN:1017-7825