Optimal Criterion for the Scale-Up Production of Schizophyllan in the Stirred Tank Reactor

Optimal Criterion for the Scale-Up Production of Schizophyllan in the Stirred Tank Reactor

Optimal criterion for the scale-up prodction of schizophyllan, a fungal polysaccharide secreted by Schizophyllum commune, was investigated. For the production of the polysaccharide in a 150-1 bioreactor, the culture conditions optimized in a 15-1 bioreactor were applied to a 150-1 bioreactor with sc...

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Veröffentlicht in:Journal of microbiology and biotechnology 2005, 15(1), , pp.1-6
Hauptverfasser: Kwak, J.K. (Technical University of Berlin, Germany), Koo, J.G. (Kunsan National University, Kunsan, Republic of Korea), Park, S.W. (Kunsan National University, Kunsan, Republic of Korea), Cho, M.G. (Dongseo University, Busan, Republic of Korea), E-mail: mgcho@gdsu.dongseo.ac.kr, Kang, B.C. (Dongseo University, Busan, Republic of Korea), Buchholz, Rainer (Technical University of Berlin, Germany), Goetz, Peter (Technical University of Berlin, Germany)
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
BIOREACTEUR
BIOREACTORS
BIORREACTORES
Biotechnology
Fundamental and applied biological sciences. Psychology
gas throughput number
Reynolds number
Scale-up process
schizophyllan
tip speed of stirrer
volume related power input
생물학
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Zusammenfassung:Optimal criterion for the scale-up prodction of schizophyllan, a fungal polysaccharide secreted by Schizophyllum commune, was investigated. For the production of the polysaccharide in a 150-1 bioreactor, the culture conditions optimized in a 15-1 bioreactor were applied to a 150-1 bioreactor with scale-up process, by changing impeller speed and airflow rate. The optimized impeller speed in the 15-1 bioreactor was 50 rpm in a technical medium based on barley.
ISSN:1017-7825