Molecular Analysis of Salmonella Enterotoxin Gene Expression

Salmonella encodes an enterotoxin which possesses biological activity similar to the cholera toxin. Stn contributes significantly to the overall virulence of S. typhimuriuim in a murine model. the production of Stn is enhanced in a high-osmolarity medium and by contact with epithelial cells. In the...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2003, 13(4), , pp.598-606
Hauptverfasser:	Lim, S.Y, Seo, H.S, Yoon, H.J, Ryu, S.Y. (Seoul Natioanl University, Suwon, Republic of Korea), Choi, S.H. (Chonnam Natioanl University, Kwangju, Republic of Korea), Heu, S.G. (National Institute of Agricultural Science and Technology, Suwon, Republic of Korea)
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology salmonella 생물학
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Beschreibung
Zusammenfassung:	Salmonella encodes an enterotoxin which possesses biological activity similar to the cholera toxin. Stn contributes significantly to the overall virulence of S. typhimuriuim in a murine model. the production of Stn is enhanced in a high-osmolarity medium and by contact with epithelial cells. In the present study, the in vitro and in vivo transcriptional regulations of the Stn promoter revealed two promoters, P1 and P2. The P1 promoter identified by a primer extension analysis of stn mRNA exhibited a switching mechanism in vivo.
ISSN:	1017-7825