Human Apolipoprotein E2 Transgenic Mice Show Lipid Accumulation in Retinal Pigment Epithelium and Altered Expression of VEGF and bFGF in the Eyes

We investigated the human apolipoprotein E2 (apoE2) transgenic mouse as an animal model system for age-related macular degeneration (AMD). Transgenic mice expressing human apoE2 and C57BL/6J mice were fed normal chow or a high-fat diet for 4 weeks. Eyes were collected from the mice and lipid deposit...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2007, 17(6), , pp.1024-1030
Hauptverfasser:	Lee, S.J. (Korea University, Seoul, Republic of Korea), Kim, J.H. (Seoul National University Hospital, Seoul, Republic of Korea), Kim, J.H. (Seoul National University, Seoul, Republic of Korea), Chung, M.J. (Korea University, Seoul, Republic of Korea), Wen, Qingcheng (Korea University, Seoul, Republic of Korea), Chung, H. (Seoul National University Hospital, Seoul, Republic of Korea), Kim, K.W. (Seoul National University, Seoul, Republic of Korea), Yu, Y.S. (Seoul National University Hospital, Seoul, Republic of Korea), E-mail: ysyu@snu.ac.kr
Format:	Artikel
Sprache:	eng
Schlagworte:	age-related macular degeneration Animals apolipoprotein E2 Apolipoprotein E2 - analysis Apolipoprotein E2 - physiology bFGF Biological and medical sciences Biotechnology Disease Models, Animal EYES Fibroblast Growth Factor 2 - analysis Fundamental and applied biological sciences. Psychology Humans Lipid Metabolism Lipoproteins, LDL - pharmacology Lipoproteins, VLDL - pharmacology Macular Degeneration - metabolism Mice Mice, Inbred C57BL OEIL OJOS Pigment Epithelium of Eye - metabolism Vascular Endothelial Growth Factor A - analysis VEGF 생물학
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Zusammenfassung:	We investigated the human apolipoprotein E2 (apoE2) transgenic mouse as an animal model system for age-related macular degeneration (AMD). Transgenic mice expressing human apoE2 and C57BL/6J mice were fed normal chow or a high-fat diet for 4 weeks. Eyes were collected from the mice and lipid deposits in retinal pigment epithelium (RPE) were assessed using electron microscopy. The expressions of apoE, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and pigment-epithelium derived factor (PEDF), which are molecular markers for angiogenesis, were assessed with immunohistochemistry.
ISSN:	1017-7825