Interleukin-2 promotes angiogenesis by activation of Akt and increase of ROS

Interleukin-2 plays a significant role in T cell proliferation. Here, we report the role of IL-2 in angiogenesis. IL-2 increased the ROS level and phosphorylation of Akt in human umbilical vein endothelial cells (HUVECs). IL-2 increased angiogenesis in an animal model and tube formation in HUVECs. T...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2008, 18(2), , pp.377-382
Hauptverfasser:	Bae, J.H. (Kangwon National University, Chuncheon, Republic of Korea), Park, D.B. (Kangwon National University, Chuncheon, Republic of Korea), Lee, Y.S. (Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea), Jeoung, D.I. (Kangwon National University, Chuncheon, Republic of Korea), E-mail: jeoungd@kangwon.ac.kr
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Angiogenic Proteins - metabolism Animals Biological and medical sciences Biotechnology CELLS Cells, Cultured CELLULE CELULAS Endothelial Cells - physiology Fundamental and applied biological sciences. Psychology Humans interleukin-2 Interleukin-2 - physiology Male Mice Mice, Inbred BALB C Neovascularization, Physiologic Phosphorylation Proto-Oncogene Proteins c-akt - metabolism reactive oxygen species Reactive Oxygen Species - metabolism serine/threonine kinase Akt Umbilical Veins - physiology 생물학
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Zusammenfassung:	Interleukin-2 plays a significant role in T cell proliferation. Here, we report the role of IL-2 in angiogenesis. IL-2 increased the ROS level and phosphorylation of Akt in human umbilical vein endothelial cells (HUVECs). IL-2 increased angiogenesis in an animal model and tube formation in HUVECs. The effect of IL-2 on angiogenesis and tube formation was mediated by ROS and Akt. This is the first report that IL-2 promotes angiogenesis.
ISSN:	1017-7825