Kitasatospora sp. MJM383 Strain Producing Two Antitumor Agents, Streptonigrin and Oxopropaline G

Kitasatospora sp. MJM383 Strain Producing Two Antitumor Agents, Streptonigrin and Oxopropaline G

MJM383, a rare actinomycete sp. strain originated from Chinese soils, was isolated through an antimicrobial screening system. The analysis of 16S rDNA sequences and biochemical characterization determined the strain to belong to genus Kitasatospora. Both NMR and ESI mass data of its purified bioacti...

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Veröffentlicht in:Journal of microbiology and biotechnology 2005, 15(5), , pp.1140-1145
Hauptverfasser: Jin, Y.Y. (Myongji University, Yongin, Republic of Korea), Yoon, T.M. (Myongji University, Yongin, Republic of Korea), Kim, W.K. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), Kim, K.R. (Myongji University, Yongin, Republic of Korea), Song, J.K. (National Institute of Agricultural Biotechnology, RDA, Suwon, Republic of Korea), Kim, J.G. (Myongji University, Yongin, Republic of Korea), Liu, J. (Myongji University, Yongin, Republic of Korea), Yang, Y.Y. (Myongji University, Yongin, Republic of Korea), Kwon, H.J. (Myongji University, Yongin, Republic of Korea), Suh, J.W. (Myongji University, Yongin, Republic of Korea), E-mail: jwsuh@mju.ac.kr
Format: Artikel
Sprache:eng
Schlagworte:
16S rDNA sequence
ACTINOMYCETALES
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Kitasatospora sp. MJM383
oxopropaline
rare actinomycete
streptonigrin
생물학
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Zusammenfassung:MJM383, a rare actinomycete sp. strain originated from Chinese soils, was isolated through an antimicrobial screening system. The analysis of 16S rDNA sequences and biochemical characterization determined the strain to belong to genus Kitasatospora. Both NMR and ESI mass data of its purified bioactive compounds revealed Kitasatospora sp. MJM383 to produce two antitumor agents, streptonigrin and oxopropaline G, which have been known to be produced from Streptomyces species. This is the first report to demonstrate the presence of antitumor agents produced by genus Kitasatospora.
ISSN:1017-7825