Effects of Aralia continentalis Root Extract on Cell Proliferation and Apoptosis in Human Promyelocytic Leukemia HL-60 Cells

The roots of Aralia continentalis (AC) have been used traditionally in Korean as a folk medicine for anti-inflammation and as an anti-rheumatic. In this study, we report that the ethyl acetate-soluble traction (ACE) of the methanolic extract of AC root inhibited the cell growth of various human canc...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2006, 16(9), , pp.1399-1404
Hauptverfasser:	Lim, H.Y. (Hanyang University, Seoul, Republic of Korea), Oh, H.L. (Hanyang University, Seoul, Republic of Korea), Lee, C.H. (Hanyang University, Seoul, Republic of Korea), E-mail: chhlee@hanyang.ac.kr
Format:	Artikel
Sprache:	eng
Schlagworte:	APOPTOSE APOPTOSIS Aralia continentalis Biological and medical sciences Biotechnology cell growth inhibition Dokwhal Fundamental and applied biological sciences. Psychology 생물학
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Zusammenfassung:	The roots of Aralia continentalis (AC) have been used traditionally in Korean as a folk medicine for anti-inflammation and as an anti-rheumatic. In this study, we report that the ethyl acetate-soluble traction (ACE) of the methanolic extract of AC root inhibited the cell growth of various human cancer cell lines and induced apoptosis of HL-60, human promyelocytic leukemia cells. Its IC∧50 values on growth inhibition were estimated to be 56.3 ㎍/ml on HL-60, 87.2 ㎍/ml on HepG2, 93.2 ㎍/ml on HeLa, 135.5 ㎍/ml on DU-145, and 135.8 ㎍/ml on HT-29 cells.
ISSN:	1017-7825