Hydroxyhibiscone A, a Novel Human Neutrophil Elastase Inhibitor from Hibiscus syriacus

Hydroxyhibiscone A, a Novel Human Neutrophil Elastase Inhibitor from Hibiscus syriacus

In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these che...

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Veröffentlicht in:Journal of microbiology and biotechnology 2010, 20(8), , pp.1189-1191
Hauptverfasser: Ryoo, I.J., Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea, Yun, B.S., Chunbuk National University, Iksan, Republic of Korea, Lee, I.K., Chunbuk National University, Iksan, Republic of Korea, Kim, Y.H., Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea, Lee, I.S., Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea, Ahn, J.S., Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea, Bae, K.H., Chungnam National University, Daejeon, Republic of Korea, Yoo, I.D., Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea
Format: Artikel
Sprache:eng
Schlagworte:
HIBISCUS SYRIACUS
human neutrophil elastase
hydroxyhibiscone A
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Zusammenfassung:In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to posses significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC∧50 values of 5.2 and 4.6 μM, respectively.
ISSN:1017-7825
DOI:10.4014/jmb.1004.04028