New Production of 5-Bromotoluhydroquinone and 4-O-Methyltoluhydroquinone from the Marine-Derived Fungus Dothideomycete sp

The addition of NaBr to the fermentation medium of a marine isolate of the fungus Dothideomycete sp. resulted in induced production of two toluhydroquinone derivatives, 5-bromotoluhydroquinone (1) and 4-O-methyltoluhydroquinone (2), and two known compounds, toluhydroquinone (3) and gentisyl alcohol...

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Veröffentlicht in:Journal of microbiology and biotechnology 2012, 22(1), , pp.80-83
Hauptverfasser: Leutou, Alain S., Pukyong National University, Busan, Republic of Korea, Yun, K.J., Pukyong National University, Busan, Republic of Korea, Choi, H.D., Dongeui University, Busan, Republic of Korea, Kang, J.S., Pusan National University, Yangsan, Republic of Korea, Son, B.W., Pukyong National University, Busan, Republic of Korea
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Sprache:eng
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Zusammenfassung:The addition of NaBr to the fermentation medium of a marine isolate of the fungus Dothideomycete sp. resulted in induced production of two toluhydroquinone derivatives, 5-bromotoluhydroquinone (1) and 4-O-methyltoluhydroquinone (2), and two known compounds, toluhydroquinone (3) and gentisyl alcohol (4). The structures of 1 and 2 were assigned through the spectroscopic data analyses. Compounds 1-4 showed a potent antibacterial activity against the methicillin-resistant and multidrug-resistant Staphylococcus aureus (MRSA and MDRSA) with MIC (minimum inhibitory concentration) values of 6.2, 12.5, 6.2, and 12.5 ㎍/ml, respectively. Compounds 1-4 also exhibited a moderate radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC∧50 values of 11.0, 17.0, 12.0, and 7.0 μM, respectively, which were more active than the positive control, L-ascorbic acid (IC∧50, 20.0 μM).
ISSN:1017-7825
1738-8872
DOI:10.4014/jmb.1108.08069