A Novel Helicosporium Isolate and Its Antimicrobial and Cytotoxic Pigment

One Helicosporium strain, isolated from a wilted chestnut tree, evidenced in vitro antimicrobial activity against various types of bacteria and fungi, and generated a diffusible pigment. The antimicrobial compounds and the diffusible pigment of the Helicosporium sp. isolate were purified via solvent...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2012, 22(9), , pp.1214-1217
Hauptverfasser:	Choi, H.J., Changwon National University, Changwon, Republic of Korea, Lee, S.M., SM Biovision Co., Ltd., Business Incubation Center, Gyeongsang National University, Jinju, Republic of Korea, Kim, S.H., Pusan National University School of Medicine, Yangsan, Republic of Korea, Kim, D.W., Changwon National University, Changwon, Republic of Korea, Choi, Y.W., Pusan National University, Miryang, Republic of Korea, Joo, W.H., Changwon National University, Changwon, Republic of Korea
Format:	Artikel
Sprache:	eng
Schlagworte:	2-methyl resorcinol Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology antimicrobial principle Ascomycota - chemistry Ascomycota - isolation & purification Ascomycota - metabolism Bacteria - drug effects Biological and medical sciences Biotechnology Cell Line, Tumor diffusible pigment Fundamental and applied biological sciences. Psychology Helicosporium Humans Inhibitory Concentration 50 mammalian cell toxicity Microbial Sensitivity Tests Nuclear Magnetic Resonance, Biomolecular PIGMENT PIGMENTOS PIGMENTS Pigments, Biological - chemistry Pigments, Biological - isolation & purification Pigments, Biological - pharmacology Resorcinols - chemistry Resorcinols - isolation & purification Resorcinols - pharmacology Trees - microbiology 생물학
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Zusammenfassung:	One Helicosporium strain, isolated from a wilted chestnut tree, evidenced in vitro antimicrobial activity against various types of bacteria and fungi, and generated a diffusible pigment. The antimicrobial compounds and the diffusible pigment of the Helicosporium sp. isolate were purified via solvent fractionation, column chromatography, and recycling preparative chromatography. Both the major antimicrobial compound and the diffusible pigment were identified as 2-methylresorcinol via nuclear magnetic resonance spectroscopy. Therefore, 2-methylresorcinol, a diffusible pigment generated by Helicosporium sp., appears to be an active antimicrobial principle. This pigment also exhibited considerable cytotoxicity against mammalian cells.
ISSN:	1017-7825 1738-8872
DOI:	10.4014/jmb.1204.04063