Proteomics for Streptomyces: "Industrial Proteomics" for Antibiotics

Streptomyces are known as a treasure box of natural organic compounds in itself as they produce over 75% of naturally-occurred bioactive compounds. Integration of genomics, proteomics, and metabolomics data which allow us to understand global and/or pathway-specific regulation, metabolism and signaling pathway, is essential for developing Streptomyces as an industrial host for antibiotics production. Owing to the burgeoning knowledge of the "-omics" data, many industrial Streptomyces strains undergone many rounds of random mutagenesis are on the verge of facing new destiny, such that several known defined mutations can make the orignal wild Streptomyces strain almost equivalent to the industrial strain.