Highly Efficient One‐Pot Solvent‐Free Synthesis of 2,5‐Disubstituted‐1,3,4‐Oxadiazole via BTI‐mediated Oxidation of N‐Acylhydrazone from Hydrazide and Aldehyde

2,5‐Disubstituted‐1,3,4‐oxadiazoles are prepared in excellent yields (up to 97%) under totally solvent‐free conditions by the quantitative formation of N‐acylhydrazone from the reaction of a hydrazide with an aldehyde using a ball‐mill for 10 min at room temperature followed by oxidation with BTI at...

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Veröffentlicht in:	Bulletin of the Korean Chemical Society 2017, 38(7), , pp.723-727
Hauptverfasser:	Yan, Xinhao, Lee, Goeun, Noh, Kyung Tak, Lee, Hyeonjin, Kim, Hakwon, Lee, Kyu Hyung, Hur, Nam Hwi, Lee, Byeongno, Park, Young Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3,4‐Oxadiazole [Bis(trifluoroacetoxy)iodo]benzene‐oxidation Ball‐mill N‐Acylhydrazone Solvent‐free 화학
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Beschreibung
Zusammenfassung:	2,5‐Disubstituted‐1,3,4‐oxadiazoles are prepared in excellent yields (up to 97%) under totally solvent‐free conditions by the quantitative formation of N‐acylhydrazone from the reaction of a hydrazide with an aldehyde using a ball‐mill for 10 min at room temperature followed by oxidation with BTI at 80°C for 1h.
ISSN:	1229-5949 0253-2964 1229-5949
DOI:	10.1002/bkcs.11160