Genetic Variations of Tyrosine Hydroxylase in the Pathogenesis of Hypertension
One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecho...
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Veröffentlicht in: | Electrolyte & blood pressure : E & BP 2016, 14(2), , pp.21-26 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of
could alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension. Here, we discuss the role of TH as a regulator of sympathetic activity and review several studies that investigated the relationship between genetic variations of
and hypertension. |
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ISSN: | 1738-5997 2092-9935 |
DOI: | 10.5049/EBP.2016.14.2.21 |