Technique failure in Korean incident peritoneal dialysis patients: A national population-based study

Abstract Background Technique failure is an important issue for peritoneal dialysis (PD) patients. In this study, we aimed to analyze a detailed technique failure rate and to determine the predictors for technique failure in Korea. Methods We identified all patients who had started dialysis between January 1, 2005 and December 31, 2008 in Korea, using the Korean Health Insurance Review and Assessment Service database. A total of 7,614 PD patients were included, and the median follow-up was 24.9 months. Results The crude incidence rates of technique failure in PD patients were 54.1 per 1000 patient-years. The cumulative 1-, 2-, and 3-year technique failure rates of PD patients were 4.9%, 10.3%, and 15.6%, respectively. However, those technique failure rates by Kaplan-Meyer analysis were overestimated compared with the values by competing risks analysis, and the differences increased with the follow-up period. In multivariate analyses, diabetes mellitus and Medical aid as a crude reflection of low socioeconomic status were independent risk factors in both Cox proportional hazard model and Fine and Gray subdistribution model. In addition, cancer was independently associated with a lower risk of technique failure in Fine and Gray model. Conclusions Technique failure was a major concern in patients initiating PD in Korea, especially in diabetic patients and Medical aid beneficiaries. The results of our study offer a basis for risk stratification for technique failure.