Hepatoprotective effect of fermented rice bran against carbon tetrachloride-induced toxicity in mice

The protective effect of fermented rice bran (GF) against carbon tetrachloride (CCl 4 )-induced hepatotoxicity in mice was investigated. Hepatic fibrosis was induced via long-term oral administration of CCl 4 . GF was added to feed. Mice sera were analyzed 8 weeks after administration. The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, both markers of hepatic injury, were reduced in the GF group. Total cholesterol (TC) and triglycerides (TG) levels were also reduced. The glutathione (GSH) level, an antioxidant in liver tissue, increased. Collagen is major component of the extracellular matrix (ECM). Persistent liver damage causes excess remodeling of liver tissue and ECM deposition, causing liver fibrosis. Liver injury was reduced and the amount of collagen, which is synthesized during recovery from liver injury, was significantly reduced in GF fed mice. Thus, the liver was protected against toxic chemicals by GF in mice with CCl 4 -induced hepatic fibrosis with an increased antioxidative reaction.