당뇨 환자에서 혈청 빌리루빈 농도와 관상동맥 미세혈관 기능과의 연관성

Background and Objectives: Bilirubin has a protective role in suppressing atherosclerosis and coronary artery disease by its potent physiological antioxidant properties. There has been no comparative study on the relation between the bilirubin level and the coronary microvascular function in diabetic patients. This study investigated whether the bilirubin level correlates with the coronary microvascular integrity in diabetes by assessing the coronary flow velocities after successful percutaneous coronary intervention (PCI). Subjects and Methods: Fifty patients (31 males and 19 females, mean age 60±11) with angina and who received elective PCI were studied. Using an intracoronary Doppler wire, the coronary flow velocity reserve (CFR), the hyperemic microvascular resistance index and the phasic coronary flow velocity patterns were measured after PCI. Results: The mean value of the fasting blood glucose was 211±88 mg/dL, the man value of glycated hemoglobin A1c (HbA1c) was 8.1±1.6% and the mean serum total bilirubin level was 0.59±0.21 mg/dL. CFR was significantly correlated with the serum bilirubin level (r=0.485, p