New cytotoxic sulfated saponins from the starfish Certonardoa semiregularis

Two new sulfated saponins designated as certonardosides P2 and I3 (1 and 2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds 1 and 2 were tested for cytotoxic...

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Veröffentlicht in:	Archives of pharmacal research 2005, 28(3), , pp.285-289
Hauptverfasser:	Wang, Weihong, Jang, Hyojin, Hong, Jongki, Lee, Chong-Ok, Bae, Song-Ja, Shin, Sook, Jung, Jee H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Humans Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Starfish - chemistry Sulfonic Acids - chemistry Sulfonic Acids - isolation & purification Sulfonic Acids - pharmacology Tumor Cells, Cultured 약학
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Zusammenfassung:	Two new sulfated saponins designated as certonardosides P2 and I3 (1 and 2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds 1 and 2 were tested for cytotoxicity against five human tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15), and compound 1 displayed significant cytotoxicity against the SK-MEL-2 skin cancer cell.
ISSN:	0253-6269 1976-3786
DOI:	10.1007/BF02977793