Butyrylcholinesterase inhibitory guaianolides from Amberboa ramosa

Butyrylcholinesterase inhibitory guaianolides from Amberboa ramosa

Phytochemical investigation of the whole plant of Amberboa ramosa led to the isolation of six sesquiterpene lactones which could be identified as 8alpha-hydroxy-11beta-methyl-1alphaH, 5alphaH, 6betaH, 7alphaH, 11alphaH-guai-10(14), 4(15)-dien-6, 12-olide(1), 3beta, 8alpha-dihydroxy-11alpha-methyl-1a...

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Veröffentlicht in:Archives of pharmacal research 2005, 28(2), , pp.172-176
Hauptverfasser: Khan, Sher Bahadar, Azhar-ul-Haq, Perveen, Shagufta, Afza, Nighat, Malik, Abdul, Nawaz, Sarfraz Ahmad, Shah, Muhammad Raza, Choudhary, Muhammad Iqbal
Format: Artikel
Sprache:eng ; kor
Schlagworte:
Asteraceae - chemistry
Butyrylcholinesterase - metabolism
Cholinesterase Inhibitors - isolation & purification
Cholinesterase Inhibitors - pharmacology
Galantamine - pharmacology
Kinetics
Sesquiterpenes, Guaiane - isolation & purification
Sesquiterpenes, Guaiane - pharmacology
Spectrometry, Mass, Electrospray Ionization
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
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Zusammenfassung:Phytochemical investigation of the whole plant of Amberboa ramosa led to the isolation of six sesquiterpene lactones which could be identified as 8alpha-hydroxy-11beta-methyl-1alphaH, 5alphaH, 6betaH, 7alphaH, 11alphaH-guai-10(14), 4(15)-dien-6, 12-olide(1), 3beta, 8alpha-dihydroxy-11alpha-methyl-1alphaH, 5alphaH, 6betaH, 7alphaH, 11betaH-guai-10(14), 4 (15)-dien-6, 12-olide (2), 3beta, 4alpha, 8alpha-trihydroxy-4beta-(hydroxymethyl)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14), 11(13)-dien-6, 12-olide (3), 3beta, 4alpha, 8alpha-trihydroxy-4beta-(chloromethyl)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14),11(13)-dien-6, 12-olide(4), 3beta, 4alpha, dihydroxy-4beta-(hydroxymethyl)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14),11(13)-dien-6, 12-olide(5), 3beta, 4alpha-dihydroxy-4beta-(chloromethyl)-8alpha-(4-hydroxymethacrylate)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14),11 (13)-dien-6,12-olide (6) by spectroscopic methods. All of them showed inhibitory potential against butyrylcholinesterase.
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02977710