Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa

Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocoryno...

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Veröffentlicht in:	Archives of pharmacal research 2007, 30(2), , pp.151-154
Hauptverfasser:	Choi, Sang Un, Baek, Nam-In, Kim, Sung-Hoon, Yang, Jae Heon, Eun, Jae Soon, Shin, Tae Yong, Lim, Jong Pil, Lee, Jae Hyeok, Jeon, Hoon, Yun, Mi-Young, Leem, Kang-Hyun, Park, Hee Wook, Kim, Dae Keun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - isolation & purification Alkaloids - pharmacology Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Cell Adhesion - drug effects Cell Line, Tumor Cell Survival - drug effects Corydalis - chemistry Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Isoquinolines - isolation & purification Isoquinolines - pharmacology Molecular Structure Neutrophils - cytology Plant Components, Aerial - chemistry Structure-Activity Relationship 약학
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Zusammenfassung:	Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells.
ISSN:	0253-6269 1976-3786
DOI:	10.1007/BF02977687