Inhibition of proliferation in colon cancer cell lines and harmful enzyme activity of colon bacteria by Bifidobacterium adolescentis SPM0212

In this study, we assessed the anticancer activity and bacterial enzyme inhibition of Bifidobacterium adolescentis SPM0212. B. adolescentis SPM0212 inhibited the proliferation of three human colon cancer cell lines: HT-29, SW 480, and Caco-2. SPM0212 also dose-dependently inhibited TNF-á production...

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Veröffentlicht in:	Archives of pharmacal research 2008, 31(4), , pp.468-473
Hauptverfasser:	Kim, Yuna, Lee, Dokyung, Kim, Donghyun, Cho, Jooyong, Yang, Jaewook, Chung, Myungjun, Kim, Kyungjae, Ha, Namjoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Asian Continental Ancestry Group Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - metabolism Base Sequence Bifidobacterium - classification Bifidobacterium - genetics Caco-2 Cells Cell Proliferation - drug effects Cell Shape - drug effects Cellulases - antagonists & inhibitors Cellulases - metabolism Colon - microbiology Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Feces - microbiology Glucuronidase - antagonists & inhibitors Glucuronidase - metabolism HT29 Cells Humans Korea Macrophages - drug effects Macrophages - metabolism Male Medicine Mice Molecular Sequence Data Pharmacology/Toxicology Pharmacy Probiotics - pharmacology Probiotics - therapeutic use Rats Rats, Sprague-Dawley Tryptophanase - metabolism Tumor Necrosis Factor-alpha - metabolism Urease - antagonists & inhibitors Urease - metabolism 약학
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Zusammenfassung:	In this study, we assessed the anticancer activity and bacterial enzyme inhibition of Bifidobacterium adolescentis SPM0212. B. adolescentis SPM0212 inhibited the proliferation of three human colon cancer cell lines: HT-29, SW 480, and Caco-2. SPM0212 also dose-dependently inhibited TNF-á production and changes in cellular morphology. B. adolescentis SPM0212 inhibited harmful fecal enzymes, including â-glucuronidase, â-glucosidase, tryptophanase, and urease. Thus, B. adolescentis SPM0212 exerts an anticancer effect and inhibits harmful fecal enzymes.
ISSN:	0253-6269 1976-3786
DOI:	10.1007/s12272-001-1180-y