Antibacterial coumarins from Angelica gigas roots

Systematic fractionation of Angelica gigas roots led to the isolation of linear furano(pyrano)coumarins such as bergapten (1), decursinol angelate (2), decursin (3), nodakenetin (4) and nodakenin (5). The antibacterial activities of those compounds against pathogenic bacteria were investigated. Amon...

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Veröffentlicht in:	Archives of pharmacal research 2003, 26(6), , pp.449-452
Hauptverfasser:	Lee, Sanghyun, Shin, Dong-Sun, Kim, Ju Sun, Oh, Ki-Bong, Kang, Sam Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	Angelica - chemistry Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Coumarins - chemistry Coumarins - isolation & purification Coumarins - pharmacology Microbial Sensitivity Tests - methods Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Roots - chemistry 약학
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Beschreibung
Zusammenfassung:	Systematic fractionation of Angelica gigas roots led to the isolation of linear furano(pyrano)coumarins such as bergapten (1), decursinol angelate (2), decursin (3), nodakenetin (4) and nodakenin (5). The antibacterial activities of those compounds against pathogenic bacteria were investigated. Among the compounds tested, decursinol angelate (2) and decursin (3) exhibited significant antibacterial activity against Bacillus subtilis with the minimum inhibitory concentrations (MICs) of 50 and 12.5 microg/mL, respectively.
ISSN:	0253-6269 1976-3786
DOI:	10.1007/BF02976860