Paroxetine hydrochloride controlled release POLYOX® matrix tablets: Screening of formulation variables using Plackett-Burman screening design
The aim of the present study was to screen the effects of the formulation variables — POLYOX® molecular weight (X 1 ), the ratio of POLYOX®/Avicel® PH102 (X 2 ) and the amount of POLYOX® and Avicel® PH102 (X 3 ), hardness (X 4 ), HPMCP amount (X 5 ), Eudragit® L100 amount (X 6 ), and citric acid amo...
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Veröffentlicht in: | Archives of pharmacal research 2008, 31(3), , pp.399-405 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The aim of the present study was to screen the effects of the formulation variables — POLYOX® molecular weight (X
1
), the ratio of POLYOX®/Avicel® PH102 (X
2
) and the amount of POLYOX® and Avicel® PH102 (X
3
), hardness (X
4
), HPMCP amount (X
5
), Eudragit® L100 amount (X
6
), and citric acid amount (X
7
) — on the paroxetine hydrochloride release from POLYOX® matrix tablet using the Plackett-Burman screening design. Paroxetine hydrochloride matrix tablets were prepared according to a 7-factor-12-run statistical model and subjected to a 8-h dissolution study in Tris buffer at pH 7.5. The regression results showed that POLYOX® molecular weight (X
1
) and POLYOX®/Avicel® PH102 ratio (X
2
) had significantly influence on the drug release mechanism and drug release rate as main effects. Hardness (X
4
) had an insignificant effect on the drug release mechanism but a significant effect on the drug release rate. On the other hand, HPMCP, Eudragit® L100 and citric acid had an insignificant effect on the both responses. The information obtained by screening design study can be expected to be useful for further formulation studies. |
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ISSN: | 0253-6269 1976-3786 |
DOI: | 10.1007/s12272-001-1170-0 |