oxepinoflavone from Artocarpus elasticus with cytotoxic activity against P-388 cells

A new oxepinoflavone, artoindonesianin E1 (1), was isolated from the wood of Artocarpus elasticus, along with four known prenylated flavones: artocarpin (2), cycloartocarpin (3), cudraflavones A (4) and C (5). The structure of the new compound was identified by spectroscopic methods. Upon cytotoxic...

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Veröffentlicht in:	Archives of pharmacal research 2009, 32(2), , pp.191-194
Hauptverfasser:	Musthapa, Iqbal, Juliawaty, Lia D, Syah, Yana M, Hakim, Euis H, Latip, Jalifah, Ghisalberti, Emilio L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Artocarpus Artocarpus - chemistry Cell Line, Tumor Cell Survival - drug effects cytotoxicity flavones Flavones - chemistry Flavones - isolation & purification Flavones - pharmacology Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - pharmacology Inhibitory Concentration 50 leukemia Medicine Mice Molecular Structure Oxepins - chemistry Oxepins - isolation & purification Oxepins - pharmacology Pharmacology/Toxicology Pharmacy spectroscopy wood 약학
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Beschreibung
Zusammenfassung:	A new oxepinoflavone, artoindonesianin E1 (1), was isolated from the wood of Artocarpus elasticus, along with four known prenylated flavones: artocarpin (2), cycloartocarpin (3), cudraflavones A (4) and C (5). The structure of the new compound was identified by spectroscopic methods. Upon cytotoxic evaluation against murine leukemia P-388 cells, the new compound showed IC₅₀ 5.0 μg/mL.
ISSN:	0253-6269 1976-3786
DOI:	10.1007/s12272-009-1134-0