Structural modification of 5,7-dimethoxyflavone from Kaempferia parviflora and biological activities

5,7-Dimethoxyflavone, a major compound from Kaempferia parviflora , was used as a starting material for structural modification. Seven flavonoid derivatives have been synthesized from this flavone. Two new oxime derivatives 4 and 6 exhibited cytotoxicity against HepG2 cell line with IC 50 values of 36.38 and 25.34 µg/mL, respectively, and against T47D cell line with IC 50 values of 41.66 and 22.94 µg/mL, respectively. Compound 7 showed cytotoxicity against HepG2 and T47D cell lines with IC 50 values of 21.36 and 25.00 µg/mL, respectively. Compounds 6 and 7 showed cytotoxicity nearly equal to the tamoxifen standard. In addition, oxime 6 exhibited antifungal activity against Candida albicans with an IC 50 value of 48.98 µg/mL.