Synthesis and antitumor screening of new 1,7-diphenyl-3-(1,3-disubstituted-1H-pyrazole-4-carbonyl)-[1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones

A new series of 3-(1,3-disubstituted-1H-pyrazole-4-carbonyl)-1,7-diphenyl-[1,2,4]triazolo[4,3- a ]pyrimidin-5(1H)-ones 4 was prepared by reaction of the enaminone 2 with hydrazonoyl halides 3 . The preliminary screening for antitumor activity of the synthesized compounds was carried out against Ehrl...

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Veröffentlicht in:	Archives of pharmacal research 2010, 33(1), , pp.55-60
Hauptverfasser:	Shawali, Ahmad S., Sherif, Sherif M., Darwish, Manal A. A., El-merzabani, Mahmoud M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - therapeutic use Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Carcinoma, Ehrlich Tumor - drug therapy Carcinoma, Ehrlich Tumor - pathology Cell Line, Tumor Doxorubicin - therapeutic use Drug Screening Assays, Antitumor Indicators and Reagents Magnetic Resonance Spectroscopy Mass Spectrometry Medicine Mice Pharmacology/Toxicology Pharmacy Pyrimidinones - chemical synthesis Pyrimidinones - pharmacology Spectrophotometry, Infrared Triazoles - chemical synthesis Triazoles - pharmacology 약학
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Zusammenfassung:	A new series of 3-(1,3-disubstituted-1H-pyrazole-4-carbonyl)-1,7-diphenyl-[1,2,4]triazolo[4,3- a ]pyrimidin-5(1H)-ones 4 was prepared by reaction of the enaminone 2 with hydrazonoyl halides 3 . The preliminary screening for antitumor activity of the synthesized compounds was carried out against Ehrlich Ascites Carcinoma tumor cells . The results revealed that the studied compounds 4 have low or no antitumor activity towards EAC tumor cells .
ISSN:	0253-6269 1976-3786
DOI:	10.1007/s12272-010-2224-8