Synthesis and anti-platelet activity of obovatol derivatives

Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives ( 1, 2, 4i ) displayed equipotent activity to obovatol in arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhib...

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Veröffentlicht in:	Archives of pharmacal research 2011, 34(7), , pp.1107-1112
Hauptverfasser:	Kwak, Jae-Hwan, Lee, Seul, Park, Eun-Seok, In, Jin-Kyung, Song, Jiho, Kim, Young Jin, Choi, Nam Song, Lee, Heesoon, Yun, Yeo-Pyo, Hong, Jin Tae, Kwak, Young-Shin, Min, Kyung Hoon, Jung, Jae-Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols - chemistry Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Arachidonic Acid - antagonists & inhibitors Arachidonic Acid - pharmacology Biphenyl Compounds - chemistry Biphenyl Compounds - pharmacology Collagen - pharmacology Dose-Response Relationship, Drug Medicine Pharmacology/Toxicology Pharmacy Phenyl Ethers - chemistry Phenyl Ethers - pharmacology Platelet Activation - drug effects Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - chemical synthesis Platelet Aggregation Inhibitors - chemistry Platelet Aggregation Inhibitors - pharmacology Rabbits Structure-Activity Relationship 약학
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Zusammenfassung:	Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives ( 1, 2, 4i ) displayed equipotent activity to obovatol in arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity.
ISSN:	0253-6269 1976-3786
DOI:	10.1007/s12272-011-0708-9