The conformation and CETP inhibitory activity of [10]-dehydrogingerdione isolated from Zingiber officinale

In the course of searching for cholesteryl ester transfer protein (CETP) inhibitors from natural sources, a new type of CETP inhibitor, [10]-dehydrogingerdione ( 1 ), was isolated from the extract of rhizomes of Zingiber officinale Roscoe. By NMR spectroscopic analysis of its 1 HNMR, 13 C-NMR, and 1 H- 1 H COSY, HMBC, HMQC and NOESY, more precise structure, compared with its originally proposed structures, of [10]-dehydrogingerdione has been elucidated. This active compound inhibited human plasma CETP with IC 50 values of 35 μM.