A new lupane-type triterpene from the seeds of Panax ginseng with its inhibition of NF-κB

A new lupane-triterpene, 3β- cis -feruloyloxy-16β-hydroxylup-20(29)-ene ( 1 ) were isolated from the ethyl acetate extract of Panax ginseng seeds along with the known compound, 3β- trans feruloyloxy-16β-hydroxylup-20(29)-ene ( 2 ). Compound 2 was isolated from this plant for the first time. Their ch...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Archives of pharmacal research 2012, 35(4), , pp.647-651
Hauptverfasser: Kim, Jeong Ah, Son, Jeong Hyun, Yang, Seo Young, Song, Seok Bean, Song, Gyu Yong, Kim, Young Ho
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A new lupane-triterpene, 3β- cis -feruloyloxy-16β-hydroxylup-20(29)-ene ( 1 ) were isolated from the ethyl acetate extract of Panax ginseng seeds along with the known compound, 3β- trans feruloyloxy-16β-hydroxylup-20(29)-ene ( 2 ). Compound 2 was isolated from this plant for the first time. Their chemical structures were determined by mass spectroscopy and one-dimensional and two-dimensional magnetic resonance spectra. The bioactive effects of these compounds on TNF-α-induced NF-κB transcription were evaluated in transfected HepG2 cells. Effects on the expression of NF-κB target genes were also examined using a reverse transcription-polymerase chain reaction. Both compounds 1 and 2 were inhibited NF-κB activity in HepG2 cells by decreasing the cellular concentrations of inflammatory factors iNOS and COX2.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-012-0408-0