A new lupane-type triterpene from the seeds of Panax ginseng with its inhibition of NF-κB
A new lupane-triterpene, 3β- cis -feruloyloxy-16β-hydroxylup-20(29)-ene ( 1 ) were isolated from the ethyl acetate extract of Panax ginseng seeds along with the known compound, 3β- trans feruloyloxy-16β-hydroxylup-20(29)-ene ( 2 ). Compound 2 was isolated from this plant for the first time. Their ch...
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Veröffentlicht in: | Archives of pharmacal research 2012, 35(4), , pp.647-651 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A new lupane-triterpene, 3β-
cis
-feruloyloxy-16β-hydroxylup-20(29)-ene (
1
) were isolated from the ethyl acetate extract of
Panax ginseng
seeds along with the known compound, 3β-
trans
feruloyloxy-16β-hydroxylup-20(29)-ene (
2
). Compound 2 was isolated from this plant for the first time. Their chemical structures were determined by mass spectroscopy and one-dimensional and two-dimensional magnetic resonance spectra. The bioactive effects of these compounds on TNF-α-induced NF-κB transcription were evaluated in transfected HepG2 cells. Effects on the expression of NF-κB target genes were also examined using a reverse transcription-polymerase chain reaction. Both compounds
1
and
2
were inhibited NF-κB activity in HepG2 cells by decreasing the cellular concentrations of inflammatory factors iNOS and COX2. |
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ISSN: | 0253-6269 1976-3786 |
DOI: | 10.1007/s12272-012-0408-0 |