Post-translational control of NF-jB signaling by ubiquitination
The transcription factor nuclear factor-kappa B(NF-jB) controls a number of essential cellular functions,including the immune response, cell proliferation, andapoptosis. NF-jB signaling must be engaged temporallyand spatially and well orchestrated to prevent aberrantactivation because loss of normal...
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Veröffentlicht in: | Archives of pharmacal research 2016, 39(8), , pp.1075-1084 |
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Sprache: | eng |
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Zusammenfassung: | The transcription factor nuclear factor-kappa B(NF-jB) controls a number of essential cellular functions,including the immune response, cell proliferation, andapoptosis. NF-jB signaling must be engaged temporallyand spatially and well orchestrated to prevent aberrantactivation because loss of normal regulation of NF-jB is amajor contributor to a variety of pathological diseases,including inflammatory diseases, autoimmune diseases,and cancers. Thus, understanding the molecular mechanismscontrolling NF-jB activation is an important part oftreatment of these relevant diseases. Although NF-jBtranscriptional activity is largely regulated by nucleartranslocation, post-translational modification of NF-jBsignaling components, including phosphorylation, ubiquitination,acetylation, and methylation, has emerged as animportant mechanism affecting activity. Many proteinshave been shown to ubiquitinate and regulate NF-jBactivation at the receptor signaling complex in response toa variety of ligands, such as tumor necrosis factor, interleukin-1, and Toll-like receptor ligands. In this review, wediscuss our current knowledge of ubiquitination patternsand their functional role in NF-jB regulation. KCI Citation Count: 2 |
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ISSN: | 0253-6269 1976-3786 |