Synthesis of novel derivatives of murrayafoline A and their inhibitory effect on LPS-stimulated production of proinflammatory cytokines in bone marrow-derived dendritic cells

A series of N-substituted-1,2,3-triazole murrayafolineAderivativeswere successfully synthesized usingclick azide–alkyne Huisgen cycloaddition reaction between1-methoxy-3-methyl-9-(3-azido)-propyl-9H-carbazole andsubstituted alkynes. Their chemical structures were confirmedby 1H, 13C NMR and HR-ESI–MS spectral data. Inaddition, the interested effects on LPS-stimulated productionof pro-inflammatory cytokines in bone marrow-deriveddendritic cells of synthetic murrayafoline A derivatives werealso investigated. Our results indicated that murrayafoline Aderivatives containing 1,2,3-triazole nucleus potentiallypossessed anti-inflammatory action through inhibiting productionof IL-6, IL-12 p40 and TNF-a. KCI Citation Count: 13