Synthesis of novel 3-allylseleno-6-alkylthiopyridazines: their anticancer activity against MCF-7 cells

A new series of 3-allylseleno-6-alkylthiopyridazines 6a – 6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer agents. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archives of pharmacal research 2014, 37(4), , pp.452-458
Hauptverfasser:	Kim, Chaewon, Kim, Saet-Byeul, Park, Myung-Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Drug Screening Assays, Antitumor Humans MCF-7 Cells Medicine Pharmacology/Toxicology Pharmacy Pyridazines - chemical synthesis Pyridazines - pharmacology Research Article Structure-Activity Relationship 약학
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A new series of 3-allylseleno-6-alkylthiopyridazines 6a – 6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer agents. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Compound 6e (3-allylseleno-6-pentylthiopyridazine) showed higher potency than 5FU for inhibiting the growth of these cell lines. This suggests the potential anticancer activity of compound 6e .
ISSN:	0253-6269 1976-3786
DOI:	10.1007/s12272-013-0244-x