6-트리아졸 엑소메칠렌펜남 유도체의 합성

6-트리아졸 엑소메칠렌펜남 유도체의 합성

The synthesis of new 6-triazole exomethylenepenams was described. The 6,6-dibromopenam 5 was reacted with $CH_3$MgBr and substituted triazole 4 to afford the 6-bromo penicillanate 6, which was treated with acetic anhydride to give acetoxy compound 7. The deacetobromination of acetoxy compound 7 with...

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Veröffentlicht in:Yaghag-hoi-ji 2004, 48(5), , pp.303-308
Hauptverfasser: 김연숙(Youn Sook Kim), 오정석(Jung Suk Oh), 임채욱(Chaeuk Im), 임철부(Chul Bu Yim)
Format: Artikel
Sprache:kor
Schlagworte:
약학
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Zusammenfassung:The synthesis of new 6-triazole exomethylenepenams was described. The 6,6-dibromopenam 5 was reacted with $CH_3$MgBr and substituted triazole 4 to afford the 6-bromo penicillanate 6, which was treated with acetic anhydride to give acetoxy compound 7. The deacetobromination of acetoxy compound 7 with zinc and acetic acid gave 6-exomethylene penams 8 and 9, which were oxidized to sulfones 10 and 11 by m-CPBA. The p-methoxybenzyl compounds 6-11 were deprotected by AlCl$_3$ and neutralized to give the sodium salts 12-17.
ISSN:0377-9556
2383-9457