유레아 및 티오유레아 유도체의 합성과 활성화된 대식세포의 NO 생성 저해효과

유레아 및 티오유레아 유도체의 합성과 활성화된 대식세포의 NO 생성 저해효과

Several ureas and thioureas were designed and synthesized and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. Among these compounds, indole-containing thiourea 6e was the most potent showing 17.4 ${\mu}M$ of $IC_{50}$ value.

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Veröffentlicht in:Yaghag-hoi-ji 2007, 51(4), , pp.246-252
Hauptverfasser: 김윤정(Yoon Jung Kim), 천예진(Ye Jin Cheon), 임효진(Hyo Jin Lim), 류재하(Jae Ha Ryu), 전라옥(Raok Jeon)
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Sprache:kor
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Zusammenfassung:Several ureas and thioureas were designed and synthesized and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. Among these compounds, indole-containing thiourea 6e was the most potent showing 17.4 ${\mu}M$ of $IC_{50}$ value.
ISSN:0377-9556
2383-9457