3-(4-Methoxybenzylaminomethylene)-1,3-dihydroindole-2-one(5-108) 화합물의 항콕시디움 효과
Coccidiosis is induced by Toxoplasma gondii and Eimeria tenella and novel anticoccidial drugs have been requested. In this study, the anticoccidial effect of 3-(4-methoxybenzylaminomethylene)-1,3-dihydroindole-2-one (5-108) on T. gondii and E. tenella was evaluated. Novel synthetic derivative 5-108...
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| Veröffentlicht in: | Yaghag-hoi-ji 2015, 59(6), , pp.266-269 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | kor |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | Coccidiosis is induced by Toxoplasma gondii and Eimeria tenella and novel anticoccidial drugs have been requested. In this study, the anticoccidial effect of 3-(4-methoxybenzylaminomethylene)-1,3-dihydroindole-2-one (5-108) on T. gondii and E. tenella was evaluated. Novel synthetic derivative 5-108 showed 1.44 fold higher relative selectivity compared to pyrimethamine against T. gondii in vitro assay. In chicken study, compound 5-108 significantly decreased the number of oocytes of E. tenella in feces, obtained from E. tenella-infected chickens, by $33{\pm}2.64%$ and $23{\pm}3.60%$ (P |
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| ISSN: | 0377-9556 2383-9457 |