A Study of HME Model in Time-Course Microarray Data

For statistical microarray data analysis, clustering analysis is a useful exploratory technique and offers the promise of simultaneously studying the variation of many genes. However, most of the proposed clustering methods are not rigorously solved for a time-course microarray data cluster and for a fitting time covariate; therefore, a statistical method is needed to form a cluster and represent a linear trend of each cluster for each gene. In this research, we developed a modified hierarchical mixture of an experts model to suggest clustering data and characterize each cluster using a linear mixed effect model. The feasibility of the proposed method is illustrated by an application to the human fibroblast data suggested by Iyer et al. (1999).