Hepatoprotective Activity of Methanol Extract of Melastoma malabathricum Leaf in Rats

The present study aimed to determine the hepatoprotective activity of a methanol extract of Melastoma malabathricum leaves (MEMM) using two established rat models. Ten groups of rats (n=6) were given a once-daily administration of 10% dimethyl sulfoxide (negative control), 200mg/kg silymarin (positi...

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Veröffentlicht in:	Journal of acupuncture and meridian studies 2013, 6(1), 21, pp.52-55
Hauptverfasser:	Kamisan, Farah Hidayah, Yahya, Farhana, Ismail, Noor Aisyah, Din, Syafawati Shamsahal, Mamat, Siti Syariah, Zabidi, Zalina, Zainulddin, Wan Noraziemah Wan, Mohtarrudin, Norhafizah, Husain, Hadijah, Ahmad, Zuraini, Zakaria, Zainul Amiruddin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals hepatoprotective activity Humans in vivo leaves Liver - drug effects Liver Diseases - drug therapy Liver Diseases - prevention & control Male Melastoma malabathricum Melastomaceae Melastomataceae - chemistry methanol extract Phytotherapy Plant Extracts - administration & dosage Plant Leaves - chemistry Protective Agents - administration & dosage Rats Rats, Sprague-Dawley 한의학
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Zusammenfassung:	The present study aimed to determine the hepatoprotective activity of a methanol extract of Melastoma malabathricum leaves (MEMM) using two established rat models. Ten groups of rats (n=6) were given a once-daily administration of 10% dimethyl sulfoxide (negative control), 200mg/kg silymarin (positive control), or MEMM (50, 250, or 500mg/kg) for 7 days followed by induction of hepatotoxicity either using paracetamol or carbon tetrachloride. Blood samples and livers were collected for biochemical and microscopic analysis. Based on the results obtained, MEMM exhibited a significant (p
ISSN:	2005-2901 2093-8152
DOI:	10.1016/j.jams.2012.08.002